Novel INHAT Repressor (NIR) is required for early lymphocyte development

Novel inhibitor of histone acetyltransferase repressor (NIR) is a transcriptional corepressor with inhibitor of histone acetyltransferase activity and is a potent suppressor of p53. Although NIR deficiency in mice leads to early embryonic lethality, lymphoid-restricted deletion resulted in the absen...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-09, Vol.111 (38), p.13930-13935
Hauptverfasser:	Ma, Chi A, Pusso, Antonia, Wu, Liming, Zhao, Yongge, Hoffmann, Victoria, Notarangelo, Luigi D, Fowlkes, B J, Jain, Ashish
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylation Animals Antigens, Differentiation - genetics Antigens, Differentiation - immunology apoptosis Biological Sciences Bone marrow Bone Marrow Cells - cytology Bone Marrow Cells - immunology cell cycle Cell Differentiation - genetics Cell Differentiation - immunology Cells Deoxyribonucleic acid DNA DNA Breaks histones Lymphocytes Mice Precursor Cells, B-Lymphoid - cytology Repressor Proteins - genetics Repressor Proteins - immunology T-lymphocytes Thymocytes - cytology Thymocytes - immunology transcription (genetics) Transcription factors Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - immunology
Online-Zugang:	Volltext
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