Genetic deletion of Rnd3 results in aqueductal stenosis leading to hydrocephalus through up-regulation of Notch signaling

Rho family guanosine triphosphatase (GTPase)3 (Rnd3), a member of the small Rho GTPase family, is involved in the regulation of cell actin cytoskeleton dynamics, cell migration, and proliferation through the Rho kinase-dependent signaling pathway. We report a role of Rnd3 in the pathogenesis of hydr...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-05, Vol.110 (20), p.8236-8241
Hauptverfasser:	Lin, Xi, Liu, Baohui, Yang, Xiangsheng, Yue, Xiaojing, Diao, Lixia, Wang, Jing, Chang, Jiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aqueducts Biological and medical sciences Biological Sciences Brain - abnormalities Cell growth Cell lines cell movement Cytoskeleton Down regulation Ependyma - cytology Ependyma - metabolism epithelium Fundamental and applied biological sciences. Psychology Gene Deletion Gene expression regulation Gene Expression Regulation, Developmental Genetics guanosinetriphosphatase HEK293 Cells Humans Hydrocephalus Hydrocephalus - metabolism Kinases Medical genetics messenger RNA Mice Mice, Knockout microfilaments mutants Mutation Neurons Oligonucleotide Array Sequence Analysis Pathogenesis Pathologic constriction precipitin tests protein degradation Protein Processing, Post-Translational Receptors, Notch - metabolism rho GTP-Binding Proteins - genetics rho GTP-Binding Proteins - metabolism RNA, Small Interfering - metabolism RNA-protein interactions Rodents Signal Transduction small interfering RNA ubiquitination Up-Regulation Vertebrates: nervous system and sense organs
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