Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis

Osteoarthritis is a complex disease involving the mechanical breakdown of articular cartilage in the presence of altered joint mechanics and chondrocyte death, but the connection between these factors is not well established. Lubricin, a mucinous glycoprotein encoded by the PRG4 gene, provides bound...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-04, Vol.110 (15), p.5852-5857
Hauptverfasser:	Waller, Kimberly A., Zhang, Ling X., Elsaid, Khaled A., Fleming, Braden C., Warman, Matthew L., Jay, Gregory D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Arthritis Biological Sciences Boundary lubrication Cartilage Cartilage - metabolism Caspase 3 - metabolism Cattle Cell Adhesion Cell Survival Chondrocytes Chondrocytes - pathology Coefficient of friction Friction Genes Genotype Glycoproteins Glycoproteins - physiology In Situ Nick-End Labeling In Vitro Techniques Joints Kinetics Knee joint Knees Male Mice Mice, Knockout Osteoarthritis Osteoarthritis - pathology Osteoarthritis - therapy Proteoglycans - genetics Proteoglycans - physiology Shear Strength Stress, Mechanical Ungulates
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