Neuronal correlates of visual time perception at brief timescales
Successful interaction with the world depends on accurate perception of the timing of external events. Neurons at early stages of the primate visual system represent time-varying stimuli with high precision. However, it is unknown whether this temporal fidelity is maintained in the prefrontal cortex...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2013-01, Vol.110 (4), p.1506-1511 |
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| creator | Mayo, J. Patrick Sommer, Marc A. |
| description | Successful interaction with the world depends on accurate perception of the timing of external events. Neurons at early stages of the primate visual system represent time-varying stimuli with high precision. However, it is unknown whether this temporal fidelity is maintained in the prefrontal cortex, where changes in neuronal activity generally correlate with changes in perception. One reason to suspect that it is not maintained is that humans experience surprisingly large fluctuations in the perception of time. To investigate the neuronal correlates of time perception, we recorded from neurons in the prefrontal cortex and midbrain of monkeys performing a temporal-discrimination task. Visual time intervals were presented at a timescale relevant to natural behavior ( |
| doi_str_mv | 10.1073/pnas.1217177110 |
| format | Article |
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Patrick ; Sommer, Marc A.</creator><creatorcontrib>Mayo, J. Patrick ; Sommer, Marc A.</creatorcontrib><description>Successful interaction with the world depends on accurate perception of the timing of external events. Neurons at early stages of the primate visual system represent time-varying stimuli with high precision. However, it is unknown whether this temporal fidelity is maintained in the prefrontal cortex, where changes in neuronal activity generally correlate with changes in perception. One reason to suspect that it is not maintained is that humans experience surprisingly large fluctuations in the perception of time. To investigate the neuronal correlates of time perception, we recorded from neurons in the prefrontal cortex and midbrain of monkeys performing a temporal-discrimination task. Visual time intervals were presented at a timescale relevant to natural behavior (<500 ms). At this brief timescale, neuronal adaptation—time-dependent changes in the size of successive responses—occurs. We found that visual activity fluctuated with timing judgments in the prefrontal cortex but not in comparable midbrain areas. Surprisingly, only response strength, not timing, predicted task performance. Intervals perceived as longer were associated with larger visual responses and shorter intervals with smaller responses, matching the dynamics of adaptation. These results suggest that the magnitude of prefrontal activity may be read out to provide temporal information that contributes to judging the passage of time.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.1217177110</identifier><identifier>PMID: 23297217</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences</publisher><subject>Adaptation, Physiological ; Animals ; Behavioral neuroscience ; Biological and medical sciences ; Biological Sciences ; Brain ; Correlation analysis ; cortex ; Discrimination (Psychology) - physiology ; Evoked Potentials, Visual - physiology ; Eye and associated structures. Visual pathways and centers. Vision ; Eyes ; Eyes & eyesight ; Fundamental and applied biological sciences. Psychology ; Humans ; Macaca mulatta - physiology ; Male ; Mesencephalon - physiology ; monkeys ; Monkeys & apes ; Neurons ; Neurons - physiology ; Neuropsychology ; Perception ; Photic Stimulation ; Prefrontal cortex ; Prefrontal Cortex - physiology ; Primates ; Reaction Time - physiology ; Saccades ; Saccades - physiology ; Sensory perception ; Superior colliculus ; Time perception ; Time Perception - physiology ; Vertebrates: nervous system and sense organs ; Visual perception ; Visual Perception - physiology</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2013-01, Vol.110 (4), p.1506-1511</ispartof><rights>copyright © 1993-2008 National Academy of Sciences of the United States of America</rights><rights>2014 INIST-CNRS</rights><rights>Copyright National Academy of Sciences Jan 22, 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c619t-ddeee742bebae3a375179da6f1560db01a5b24e5f6a173315bade2de383ff2b03</citedby><cites>FETCH-LOGICAL-c619t-ddeee742bebae3a375179da6f1560db01a5b24e5f6a173315bade2de383ff2b03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/110/4.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/41991802$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/41991802$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27204644$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23297217$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mayo, J. Patrick</creatorcontrib><creatorcontrib>Sommer, Marc A.</creatorcontrib><title>Neuronal correlates of visual time perception at brief timescales</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Successful interaction with the world depends on accurate perception of the timing of external events. Neurons at early stages of the primate visual system represent time-varying stimuli with high precision. However, it is unknown whether this temporal fidelity is maintained in the prefrontal cortex, where changes in neuronal activity generally correlate with changes in perception. One reason to suspect that it is not maintained is that humans experience surprisingly large fluctuations in the perception of time. To investigate the neuronal correlates of time perception, we recorded from neurons in the prefrontal cortex and midbrain of monkeys performing a temporal-discrimination task. Visual time intervals were presented at a timescale relevant to natural behavior (<500 ms). At this brief timescale, neuronal adaptation—time-dependent changes in the size of successive responses—occurs. We found that visual activity fluctuated with timing judgments in the prefrontal cortex but not in comparable midbrain areas. Surprisingly, only response strength, not timing, predicted task performance. Intervals perceived as longer were associated with larger visual responses and shorter intervals with smaller responses, matching the dynamics of adaptation. These results suggest that the magnitude of prefrontal activity may be read out to provide temporal information that contributes to judging the passage of time.</description><subject>Adaptation, Physiological</subject><subject>Animals</subject><subject>Behavioral neuroscience</subject><subject>Biological and medical sciences</subject><subject>Biological Sciences</subject><subject>Brain</subject><subject>Correlation analysis</subject><subject>cortex</subject><subject>Discrimination (Psychology) - physiology</subject><subject>Evoked Potentials, Visual - physiology</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Eyes</subject><subject>Eyes & eyesight</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Macaca mulatta - physiology</subject><subject>Male</subject><subject>Mesencephalon - physiology</subject><subject>monkeys</subject><subject>Monkeys & apes</subject><subject>Neurons</subject><subject>Neurons - physiology</subject><subject>Neuropsychology</subject><subject>Perception</subject><subject>Photic Stimulation</subject><subject>Prefrontal cortex</subject><subject>Prefrontal Cortex - physiology</subject><subject>Primates</subject><subject>Reaction Time - physiology</subject><subject>Saccades</subject><subject>Saccades - physiology</subject><subject>Sensory perception</subject><subject>Superior colliculus</subject><subject>Time perception</subject><subject>Time Perception - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Visual perception</subject><subject>Visual Perception - physiology</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v1DAQxS0EotvCmRMQCSFxSTvjz-SCVFXlQ6rgAD1bTjIuWWXjYCeV-O_xdpdt4cLJkt9v3rPnMfYC4RTBiLNpdOkUORo0BhEesRVCjaWWNTxmKwBuykpyecSOU1oDQK0qeMqOuOC1yVMrdv6FlhhGNxRtiJEGN1Mqgi9u-7Tky7nfUDFRbGma-zAWbi6a2JO_E1LrBkrP2BPvhkTP9-cJu_5w-f3iU3n19ePni_OrstVYz2XXEZGRvKHGkXDCKDR157RHpaFrAJ1quCTltUMjBKrGdcQ7EpXwnjcgTtj7ne-0NBvqWhrn6AY7xX7j4i8bXG__Vsb-h70Jt1YoZcCobPBubxDDz4XSbDd9amkY3EhhSRYrEIgatPw_yo2okEtdZfTNP-g6LDEv9I4ylYLKYKbOdlQbQ0qR_OHdCHbbpN02ae-bzBOvHn73wP-pLgNv94DbFuGjG9s-3XOGg9RSPjDaJhxic660qEBn4OUOWKc5xAMhsa7zSnjWX-9074J1NzGHXH_jkDcFKFFk4jcbg8PH</recordid><startdate>20130122</startdate><enddate>20130122</enddate><creator>Mayo, J. Patrick</creator><creator>Sommer, Marc A.</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20130122</creationdate><title>Neuronal correlates of visual time perception at brief timescales</title><author>Mayo, J. Patrick ; Sommer, Marc A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c619t-ddeee742bebae3a375179da6f1560db01a5b24e5f6a173315bade2de383ff2b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adaptation, Physiological</topic><topic>Animals</topic><topic>Behavioral neuroscience</topic><topic>Biological and medical sciences</topic><topic>Biological Sciences</topic><topic>Brain</topic><topic>Correlation analysis</topic><topic>cortex</topic><topic>Discrimination (Psychology) - physiology</topic><topic>Evoked Potentials, Visual - physiology</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Eyes</topic><topic>Eyes & eyesight</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Macaca mulatta - physiology</topic><topic>Male</topic><topic>Mesencephalon - physiology</topic><topic>monkeys</topic><topic>Monkeys & apes</topic><topic>Neurons</topic><topic>Neurons - physiology</topic><topic>Neuropsychology</topic><topic>Perception</topic><topic>Photic Stimulation</topic><topic>Prefrontal cortex</topic><topic>Prefrontal Cortex - physiology</topic><topic>Primates</topic><topic>Reaction Time - physiology</topic><topic>Saccades</topic><topic>Saccades - physiology</topic><topic>Sensory perception</topic><topic>Superior colliculus</topic><topic>Time perception</topic><topic>Time Perception - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Visual perception</topic><topic>Visual Perception - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mayo, J. 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Patrick</au><au>Sommer, Marc A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuronal correlates of visual time perception at brief timescales</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2013-01-22</date><risdate>2013</risdate><volume>110</volume><issue>4</issue><spage>1506</spage><epage>1511</epage><pages>1506-1511</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>Successful interaction with the world depends on accurate perception of the timing of external events. Neurons at early stages of the primate visual system represent time-varying stimuli with high precision. However, it is unknown whether this temporal fidelity is maintained in the prefrontal cortex, where changes in neuronal activity generally correlate with changes in perception. One reason to suspect that it is not maintained is that humans experience surprisingly large fluctuations in the perception of time. To investigate the neuronal correlates of time perception, we recorded from neurons in the prefrontal cortex and midbrain of monkeys performing a temporal-discrimination task. Visual time intervals were presented at a timescale relevant to natural behavior (<500 ms). At this brief timescale, neuronal adaptation—time-dependent changes in the size of successive responses—occurs. We found that visual activity fluctuated with timing judgments in the prefrontal cortex but not in comparable midbrain areas. Surprisingly, only response strength, not timing, predicted task performance. Intervals perceived as longer were associated with larger visual responses and shorter intervals with smaller responses, matching the dynamics of adaptation. These results suggest that the magnitude of prefrontal activity may be read out to provide temporal information that contributes to judging the passage of time.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences</pub><pmid>23297217</pmid><doi>10.1073/pnas.1217177110</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adaptation, Physiological Animals Behavioral neuroscience Biological and medical sciences Biological Sciences Brain Correlation analysis cortex Discrimination (Psychology) - physiology Evoked Potentials, Visual - physiology Eye and associated structures. Visual pathways and centers. Vision Eyes Eyes & eyesight Fundamental and applied biological sciences. Psychology Humans Macaca mulatta - physiology Male Mesencephalon - physiology monkeys Monkeys & apes Neurons Neurons - physiology Neuropsychology Perception Photic Stimulation Prefrontal cortex Prefrontal Cortex - physiology Primates Reaction Time - physiology Saccades Saccades - physiology Sensory perception Superior colliculus Time perception Time Perception - physiology Vertebrates: nervous system and sense organs Visual perception Visual Perception - physiology |
| title | Neuronal correlates of visual time perception at brief timescales |
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