Borna disease virus-induced neuronal degeneration dependent on host genetic background and prevented by soluble factors

Infection of newborn rats with Borne disease virus (BDV) results in selective degeneration of granule cell neurons of the dentate gyrus (DG). To study cellular countermechanisms that might prevent this pathology, we screened for rat strains resistant to this BDV-induced neuronal degeneration. To thi...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-01, Vol.110 (5), p.1899-1904
Hauptverfasser:	Wu, Yuan-Ju, Schulz, Herbert, Lin, Chia-Ching, Saar, Kathrin, Patone, Giannino, Fischer, Heike, Hübner, Norbert, Heimrich, Bernd, Schwemmle, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Biological Factors - chemistry Biological Factors - pharmacology Biological Sciences Borna disease Borna disease virus Borna disease virus - physiology Brain-Derived Neurotrophic Factor - pharmacology Cell culture Cell Survival - drug effects cell viability Chromosome Mapping Chromosomes, Mammalian - genetics crossing Culture Media, Conditioned - chemistry Culture Media, Conditioned - pharmacology Cultured cells Dentate Gyrus - metabolism Dentate Gyrus - pathology Dentate Gyrus - virology Disease Resistance - genetics Female genetic background Genetic loci Genetics genome-wide association study Genomics Hippocampus Hippocampus - metabolism Hippocampus - pathology Hippocampus - virology Host-Pathogen Interactions Infections loci Male Medical genetics neonates Nerve Degeneration - genetics Nerve Degeneration - prevention & control Nerve Degeneration - virology Neurodegeneration Neurons Neurons - metabolism Neurons - pathology Neurons - virology Polymorphism, Single Nucleotide progeny Pyramidal cells Rats Rats, Inbred Lew Rats, Sprague-Dawley Rodents Solubility Species Specificity Survival analysis Tissue Culture Techniques virus replication Viruses
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