Links between Replication and Recombination in Saccharomyces cerevisiae: A Hypersensitive Requirement for Homologous Recombination in the Absence of Rad27 Activity

The RAD27 gene of Saccharomyces cerevisiae encodes a 5′-3′ flap exo/endonuclease, which plays an important role during DNA replication for Okazaki fragment maturation. Genetic studies have shown that RAD27 is not essential for growth, although rad27Δ mutants are temperature sensitive. Moreover, they...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2001-07, Vol.98 (15), p.8263-8269
Hauptverfasser:	Debrauwère, H, Loeillet, S, Lin, W, Lopes, J, Nicolas, A
Format:	Artikel
Sprache:	eng
Schlagworte:	5'-3' flap exo/endonuclease Alleles Cell growth Colloquium: Links between Recombination and Replication: Vital Roles of Recombination com1 gene Deoxyribonucleic acid Diploidy DNA DNA Helicases - metabolism DNA Repair DNA Replication DNA, Fungal - biosynthesis DNA-Binding Proteins - metabolism Endodeoxyribonucleases - genetics Endodeoxyribonucleases - physiology Endonucleases Exodeoxyribonucleases Flap Endonucleases Fungal Proteins - genetics Fungal Proteins - metabolism Fungal Proteins - physiology Genetic mutation Genetics Haploidy Homologous recombination mre11s gene Phenotypes RAD27 gene rad27 protein rad50 gene Rad52 DNA Repair and Recombination Protein Rad52 protein Recombination, Genetic RecQ Helicases Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins sae2 gene Spores srs2 gene Viability Yeast
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