Capture and imaging of a prehairpin fusion intermediate of the paramyxovirus PIV5

During cell entry, enveloped viruses fuse their viral membrane with a cellular membrane in a process driven by energetically favorable, large-scale conformational rearrangements of their fusion proteins. Structures of the pre- and postfusion states of the fusion proteins including paramyxovirus PIV5...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-12, Vol.108 (52), p.20992-20997
Hauptverfasser:	Kim, Yong Ho, Donald, Jason E, Grigoryan, Gevorg, Leser, George P, Fadeev, Alexander Y, Lamb, Robert A, DeGrado, William F
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Biochemistry Biological Sciences Cell Membrane - metabolism Cell membranes Chromatography, High Pressure Liquid Computational modeling Computed tomography Crystallography Electron microscopy Fusion protein Hemagglutinins Hydrophobicity image analysis Immunohistochemistry Influenza Influenza A virus Influenza virus Lipids Mathematical models Membranes Microscopy, Electron, Transmission Models, Biological Orthomyxoviridae Paramyxoviridae - metabolism Paramyxovirus plasma membrane Protein Conformation Protein Folding Proteins Respirovirus spatial distribution Ultracentrifugation Viral Fusion Proteins - metabolism Viral morphology Virions Virus Attachment Viruses
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