Schizophrenia susceptibility gene dysbindin regulates glutamatergic and dopaminergic functions via distinctive mechanisms in Drosophila

The dysfunction of multiple neurotransmitter systems is a striking pathophysiological feature of many mental disorders, schizophrenia in particular, but delineating the underlying mechanisms has been challenging. Here we show that manipulation of a single schizophrenia susceptibility gene, dysbindin...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2011-11, Vol.108 (46), p.18831-18836
Hauptverfasser: Shao, Lisha, Shuai, Yichun, Wang, Jie, Feng, Shanxi, Lu, Binyan, Li, Zuo, Zhao, Yukai, Wang, Lianzhang, Zhong, Yi
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Sprache:eng
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