Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli

Transient receptor potential (TRP) channels are polymodal signal detectors that respond to a wide array of physical and chemical stimuli, making them important components of sensory systems in both vertebrate and invertebrate organisms. Mammalian TRPA1 channels are activated by chemically reactive i...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-11, Vol.108 (46), p.E1184-E1191
Hauptverfasser:	Cordero-Morales, Julio F, Gracheva, Elena O, Julius, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences calcium Crotalus Cytoplasm Cytoplasm - metabolism detectors Dimerization Drosophila Drosophila melanogaster Drosophila Proteins - chemistry Drosophila Proteins - metabolism Electrophysiology - methods evolution heat Hot Temperature Humans invertebrates mammals Neurons Oocytes - metabolism Physiology PNAS Plus Point Mutation Protein Structure, Tertiary Proteins Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism RNA, Complementary - metabolism sensory neurons Snakes Transient Receptor Potential Channels - chemistry Transient Receptor Potential Channels - metabolism TRPA1 Cation Channel TRPC Cation Channels - chemistry TRPC Cation Channels - metabolism Xenopus Xenopus laevis - metabolism Zebrafish
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