Large collective motions regulate the functional properties of glutamate transporter trimers

Glutamate transporters clear synaptically released glutamate to maintain precise communication between neurons and limit glutamate neurotoxicity. Although much progress has been made on the topology, structure, and function of these carriers, few studies have addressed large-scale structural motions...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-09, Vol.108 (37), p.15141-15146
Hauptverfasser:	Jiang, Jie, Shrivastava, Indira H, Watts, Spencer D, Bahar, Ivet, Amara, Susan G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution - genetics Amino Acid Transport System X-AG - chemistry Amino Acid Transport System X-AG - metabolism Amino acid transport system XAG amino acid transporters Amino acids Anions Anions - metabolism Anisotropy Biological Sciences Biological Transport Cadmium - metabolism Cross-Linking Reagents - metabolism crosslinking Crystal structure cysteine Cysteine - genetics Cytoplasm disulfide bonds Disulfides Electric current Excitatory Amino Acid Transporter 1 - chemistry Excitatory Amino Acid Transporter 1 - metabolism functional properties Humans Ion Channel Gating Membranes Models, Biological Models, Molecular Motion Mutant Proteins - chemistry Mutant Proteins - metabolism mutants Mutation Neurons neurotoxicity Oocytes Phenanthrolines - metabolism Protein Multimerization Protein Structure, Secondary Protein Subunits - chemistry Protein Subunits - metabolism Proteins Reagents topology Trimers
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