Animal-specific C-terminal domain links myeloblastosis oncoprotein (Myb) to an ancient repressor complex

Members of the Myb oncoprotein and E2F-Rb tumor suppressor protein families are present within the same highly conserved multiprotein transcriptional repressor complex, named either as Myb and synthetic multivuval class B (Myb-MuvB) or as Drosophila Rb E2F and Myb-interacting proteins (dREAM). We no...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-10, Vol.108 (42), p.17438-17443
Hauptverfasser:	Andrejka, Laura, Wen, Hong, Ashton, Jonathan, Grant, Megan, Iori, Kevin, Wang, Amy, Manak, J. Robert, Lipsick, Joseph S.
Format:	Artikel
Sprache:	eng
Schlagworte:	adults Amino Acid Sequence Animals Animals, Genetically Modified Binding sites Binding Sites - genetics Biological Sciences Breast cancer breast neoplasms Breast Neoplasms - genetics Cell Cycle Proteins - genetics Chromosomes Conserved Sequence Deoxyribonucleic acid DNA Dreams Drosophila Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - chemistry Drosophila Proteins - genetics Drosophila Proteins - metabolism Drug development E2F protein Evolution Evolution, Molecular Female Gene expression gene expression regulation Genes Genes, myb Humans Male Molecular Sequence Data Mutagenesis, Site-Directed Mutant proteins Mutant Proteins - chemistry Mutant Proteins - genetics Mutant Proteins - metabolism MYB protein Oncogene Proteins v-myb - chemistry Oncogene Proteins v-myb - genetics Oncogene Proteins v-myb - metabolism Oncogenes patients Phenotypes Prognosis protein families Protein Structure, Tertiary Proteins Repressor Proteins - chemistry Repressor Proteins - genetics Repressor Proteins - metabolism Repressors Retinoblastoma protein Sequence Homology, Amino Acid therapeutics Trans-Activators - genetics Transcription transcription (genetics) Transcription factors Tumor suppressor genes Tumors Viability
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