Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration

We introduce a human retinal pigmented epithelial (RPE) cell-culture model that mimics several key aspects of early stage age-related macular degeneration (AMD). These include accumulation of sub-RPE deposits that contain molecular constituents of human drusen, and activation of complement leading t...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-11, Vol.108 (45), p.18277-18282
Hauptverfasser:	Johnson, Lincoln V, Forest, David L, Banna, Christopher D, Radeke, Carolyn M, Maloney, Michelle A, Hu, Jane, Spencer, Christine N, Walker, Aimee M, Tsie, Marlene S, Bok, Dean, Radeke, Monte J, Anderson, Don H
Format:	Artikel
Sprache:	eng
Schlagworte:	Accretion Accumulation apolipoprotein E Apolipoproteins E - metabolism Biological Sciences Blood proteins Cell culture Cell Culture Techniques Cell growth Cell membranes Cellular immunity complement Complement Activation complications (disease) Cultured cells Drusen Humans Immunohistochemistry Lipids Macular degeneration Macular Degeneration - metabolism Macular Degeneration - pathology Models, Biological Molecules pathogenesis Proteins Retinal Drusen - pathology Retinal Pigment Epithelium - metabolism Retinal Pigment Epithelium - pathology
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