Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice

Vertebrates typically harbor a rich gastrointestinal microbiota, which has coevolved with the host over millennia and is essential for several host physiological functions, in particular maturation of the immune system. Recent studies have highlighted the importance of a single bacterial species, se...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-07, Vol.108 (28), p.11548-11553
Hauptverfasser:	Kriegel, Martin A, Sefik, Esen, Hill, Jonathan A, Wu, Hsin-Jung, Benoist, Christophe, Mathis, Diane
Format:	Artikel
Sprache:	eng
Schlagworte:	animal disease models Animal models Animals Arthritis Autoimmune diseases Autoimmunity Bacteria Bacteria - genetics Bacteria - immunology Bacteria - isolation & purification Base Sequence Biological Sciences CD4 antigen CD4-positive T-lymphocytes CD4-Positive T-Lymphocytes - immunology coevolution Colonization Commensals Diabetes Diabetes mellitus Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - microbiology Diabetes Mellitus, Type 1 - prevention & control Digestive tract DNA, Bacterial - genetics DNA, Bacterial - isolation & purification encephalitis Experimental allergic encephalomyelitis Female females Filamentous bacteria gastrointestinal system Gastrointestinal Tract - immunology Gastrointestinal Tract - microbiology Helper cells Immune system Inflammation insulin-dependent diabetes mellitus Insulitis lamina propria Lymphocytes Lymphocytes T Lymphoid tissue Male males Metagenome Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred NOD Microbial colonization Microbiota Mucosa Oligonucleotide Array Sequence Analysis Pancreas Pedigree penetrance Rodents T cell receptors Th17 Cells - immunology tissues Type 1 diabetes mellitus
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