CNS expression of glucocerebrosidase corrects α-synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy

Emerging genetic and clinical evidence suggests a link between Gaucher disease and the synucleinopathies Parkinson disease and dementia with Lewy bodies. Here, we provide evidence that a mouse model of Gaucher disease (Gba1D409V/D409V) exhibits characteristics of synucleinopathies, including progres...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-07, Vol.108 (29), p.12101-12106
Hauptverfasser:	Sardi, S. Pablo, Clarke, Jennifer, Kinnecom, Cathrine, Tamsett, Thomas J., Li, Lingyun, Stanek, Lisa M., Passini, Marco A., Grabowski, Gregory A., Schlossmacher, Michael G., Sidman, Richard L., Cheng, Seng H., Shihabuddin, Lamya S.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - metabolism Analysis of Variance Animals Biological Sciences Blotting, Western Brain Central nervous system Dependovirus Disease models Endopeptidase K - metabolism Gaucher disease Gaucher Disease - metabolism Gaucher Disease - pathology Gene Transfer Techniques Genetic mutation Genetic Vectors - genetics Glucosylceramidase - genetics Glucosylceramidase - metabolism Hippocampus Hippocampus - cytology Hippocampus - enzymology Immunohistochemistry Memory Mice Parkinson disease Pathology Ubiquitins
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