Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells

Drugs that target novel surfaces on the androgen receptor (AR) and/or novel AR regulatory mechanisms are promising alternatives for the treatment of castrate-resistant prostate cancer. The 52 kDa FK506 binding protein (FKBP52) is an important positive regulator of AR in cellular and whole animal mod...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-07, Vol.108 (29), p.11878-11883
Hauptverfasser:	De Leon, Johanny Tonos, Iwai, Aki, Feau, Clementine, Garcia, Yenni, Balsiger, Heather A, Storer, Cheryl L, Suro, Raquel M, Garza, Kristine M, Lee, Sunmin, Sang Kim, Yeong, Chen, Yu, Ning, Yang-Min, Riggs, Daniel L, Fletterick, Robert J, Guy, R. Kiplin, Trepel, Jane B, Neckers, Leonard M, Cox, Marc B
Format:	Artikel
Sprache:	eng
Schlagworte:	androgen receptors Androgens animal models Animals beta-Galactosidase Biological Sciences Cell growth Cell Line, Tumor Cell lines cell proliferation Cell Proliferation - drug effects dissociation Drug Discovery drugs Enzyme-Linked Immunosorbent Assay Fluorescence Gene expression Gene Expression Regulation - drug effects Heat shock proteins Hormones HSP90 Heat-Shock Proteins - metabolism Humans Immunoblotting Immunoprecipitation Libraries Male Mice Models, Molecular Molecular Dynamics Simulation Molecular Structure Molecules Multiprotein Complexes - metabolism neoplasm cells Prostate cancer prostatic neoplasms Prostatic Neoplasms - metabolism Receptors Receptors, Androgen - chemistry Receptors, Androgen - metabolism Signal transduction T cell receptors Tacrolimus Binding Proteins - antagonists & inhibitors Tacrolimus Binding Proteins - metabolism Yeasts
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