Anthrax Lethal Factor Represses Glucocorticoid and Progesterone Receptor Activity

We report here that a bacterial toxin, anthrax lethal toxin (LeTx), at very low concentrations represses glucocorticoid receptor (GR) transactivation in a transient transfection system and the activity of an endogenous GR-regulated gene in both a cellular system and an animal model. This repression...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-05, Vol.100 (10), p.5706-5711
Hauptverfasser:	Webster, Jeanette I., Tonelli, Leonardo H., Moayeri, Mahtab, Simons, S. Stoney, Leppla, Stephen H., Sternberg, Esther M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthrax Antigens, Bacterial Bacillus anthracis Bacterial Toxins - pharmacology Biological Sciences Cell lines Cercopithecus aethiops COS Cells Dexamethasone - pharmacology Enzyme Inhibitors - pharmacology Female Flavonoids - pharmacology Gene Expression Regulation - drug effects Hormone receptors Kinetics Male Mice Mice, Inbred BALB C Mifepristone - pharmacology Mitogen-Activated Protein Kinases - antagonists & inhibitors Receptors Receptors, Glucocorticoid - antagonists & inhibitors Receptors, Progesterone - antagonists & inhibitors Recombinant Proteins - antagonists & inhibitors Repression Standard deviation Toxicity Toxins Transactivation Transfection
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