Epidermal Growth Factor Receptor Signaling Intensity Determines Intracellular Protein Interactions, Ubiquitination, and Internalization

Ligand activation of the epidermal growth factor receptor (EGFR) causes the binding of Cbls, which leads to EGFR polyubiquitination and internalization through endophilin complexes that contain the adaptor protein SH3-domain encoding, expressed in tumorigenic astrocytes/Cbl-interacting protein of 85...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-05, Vol.100 (11), p.6505-6510
Hauptverfasser:	Mirko H. H. Schmidt, Furnari, Frank B., Cavenee, Webster K., Bögler, Oliver
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Cell division Cell Line CHO cells Cricetinae Endocytosis Glioma Growth factor receptors HEK293 cells Humans Ice Internalization Oncogenes Phosphorylation Proteins Receptor, Epidermal Growth Factor - metabolism Receptors Signal Transduction Skin Ubiquitin - metabolism
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