RA-inducible gene-I induction augments STAT1 activation to inhibit leukemia cell proliferation

RA-inducible gene I (RIG-I/DDX58) has been shown to activate IFN-β promoter stimulator 1 (IPS-1) on recognizing cytoplasmic viral RNAs. It is unclear how RIG-I functions within the IFN and/or RA signaling process in acute myeloid leukemia (AML) cells, however, where obvious RIG-I induction is observ...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-02, Vol.108 (5), p.1897-1902
Hauptverfasser:	Jiang, Lin-Jia, Zhang, Nan-Nan, Ding, Fei, Li, Xian-Yang, Chen, Lei, Zhang, Hong-Xin, Zhang, Wu, Chen, Sai-Juan, Wang, Zhu-Gang, Li, Jun-Min, Chen, Zhu, Zhu, Jiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia alpha -Interferon beta -Interferon Biological Sciences Cell cycle Cell growth Cell lines Cell Proliferation Cells DEAD Box Protein 58 DEAD-box RNA Helicases - genetics Gene expression Gene Expression Regulation - drug effects Genes Humans Interferon Leukemia Leukemia - pathology Messenger RNA Myeloid cells Myeloid leukemia Phosphorylation Plasmids Promoters Receptors, Immunologic Signal transduction Stat1 protein STAT1 Transcription Factor - metabolism Stem cells Transcription Tretinoin - pharmacology U937 Cells
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