Coexpression of VEGF and angiopoietin-1 promotes angiogenesis and cardiomyocyte proliferation reduces apoptosis in porcine myocardial infarction (MI) heart

VEGF and angiopoietin-1 (Ang1) are two major angiogenic factors being investigated for the treatment of myocardial infarction (MI). Targeting VEGF and Ang1 expression in the ischemic myocardium can increase their local therapeutic effects and reduce possible adverse effects. Adeno-associated viral v...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-02, Vol.108 (5), p.2064-2069
Hauptverfasser:	Tao, Zhengxian, Chen, Bo, Tan, Xiao, Zhao, Yingming, Wang, Liansheng, Zhu, Tiebing, Cao, Kejiang, Yang, Zhijian, Kan, Yuet Wai, Su, Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiopoietin-1 - metabolism Angiopoietin-1 - physiology Animals Apoptosis Biological Sciences Cardiac output Cardiomyocytes Cell Proliferation Computed tomography Coronary Vessels - growth & development Cyclins Gene expression Genetic vectors Heart Heart attacks Hogs Hypoxia Myocardial infarction Myocardial Infarction - pathology Myocardium Myocardium - pathology Neovascularization, Physiologic Perfusion Phosphorylation Swine Tomography Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor A - physiology
Online-Zugang:	Volltext
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