Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase

Alcohol's deleterious effects on memory are well known. Acute alcohol-induced memory loss is thought to occur via inhibition of NMDA receptor (NMDAR)-dependent long-term potentiation in the hippocampus. We reported previously that ethanol inhibition of NMDAR function and long-term potentiation...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-04, Vol.108 (16), p.6650-6655
Hauptverfasser:	Hicklin, Tianna R, Wu, Peter H, Radcliffe, Richard A, Freund, Ronald K, Goebel-Goody, Susan M, Correa, Paulo R, Proctor, William R, Lombroso, Paul J, Browning, Michael D
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Amnesia - chemically induced Amnesia - enzymology Amnesia - genetics Animals Behavioral neuroscience Biological Sciences Brain Cells Central Nervous System Depressants - adverse effects Central Nervous System Depressants - pharmacology Data processing Dephosphorylation Effects Enzymes Ethanol Ethanol - adverse effects Ethanol - pharmacology Excitatory postsynaptic potentials Fear - drug effects Fear conditioning fearfulness Freezing Glutamic acid receptors Glutamic acid receptors (ionotropic) Hippocampus Humans Learning Learning - drug effects Long term potentiation Long-Term Potentiation - drug effects Long-Term Potentiation - genetics Memory Mice Mice, Knockout N methyl D aspartate receptors N-Methyl-D-aspartic acid receptors Neurons Phosphatases Phosphorylation Phosphorylation - drug effects Phosphorylation - genetics Protein Tyrosine Phosphatases, Non-Receptor - genetics Protein Tyrosine Phosphatases, Non-Receptor - metabolism Protein-tyrosine-phosphatase Receptor mechanisms Receptors Receptors, N-Methyl-D-Aspartate - genetics Receptors, N-Methyl-D-Aspartate - metabolism Synaptic Potentials - drug effects Synaptic Potentials - genetics tyrosine
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