Glycolytic rate and lymphomagenesis depend on PARP14, an ADP ribosyltransferase of the B aggressive lymphoma (BAL) family

Poly(ADP-ribose)polymerase (PARP)14—a member of the B aggressive lymphoma (BAL) family of macrodomain-containing PARPs—is an ADP ribosyltransferase that interacts with Stat6, enhances induction of certain genes by IL-4, and is expressed in B lymphocytes. We now show that IL-4 enhancement of glycolys...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-09, Vol.108 (38), p.15972-15977
Hauptverfasser:	Cho, Sung Hoon, Ahn, Annie K, Bhargava, Prerna, Lee, Chih-Hao, Eischen, Christine M, McGuinness, Owen, Boothby, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-activated protein kinase AMP-Activated Protein Kinases - metabolism Animals Apoptosis Apoptosis - drug effects B lymphocytes B-Lymphocytes - metabolism B-Lymphocytes - pathology Biological Sciences Biological Transport - drug effects Bone marrow cells carcinogenesis Cell lines Cells Cells, Cultured Cellular metabolism Cultured cells Enzyme Activation - drug effects Female Gene expression Glucose - metabolism Glucose - pharmacokinetics Glycolysis Immunoblotting In Situ Nick-End Labeling interleukin-4 Interleukin-4 - pharmacology Kinases Lymphocytes Lymphoma Lymphoma - genetics Lymphoma - metabolism Lymphoma - pathology Male mammals Mice Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout Mitochondria - drug effects Mitochondria - metabolism NAD ADP-ribosyltransferase oncogenes Oxidative Phosphorylation - drug effects Poly(ADP-ribose) Polymerases - genetics Poly(ADP-ribose) Polymerases - metabolism Signal transduction STAT6 Transcription Factor - genetics STAT6 Transcription Factor - metabolism Survival Analysis T lymphocytes
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