Requirement for kinase-induced conformational change in eukaryotic initiation factor 2α (elF2α) restricts phosphorylation of Ser51

As phosphorylation of eukaryotic translation initiation factor 2α (elF2α) on Ser51 inhibits protein synthesis, cells restrict this phosphorylation to the antiviral protein kinase PKR and related elF2a kinases. In the crystal structure of the PKR-elF2α complex, the C-terminal lobe of the kinase conta...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-03, Vol.108 (11), p.4316-4321
Hauptverfasser:	Dey, Madhusudan, Velyvis, Algirdas, Li, John J., Chiu, Elaine, Chiovitti, David, Kay, Lewis E., Sicheri, Frank, Dever, Thomas E., Kuriyan, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Active sites Biological Sciences Gene expression regulation Genetic mutation Peptide initiation factors Phenotypes Phosphorylation Plasmids Protein synthesis Proteins Yeasts
Online-Zugang:	Volltext
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