Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus

Streptomyces clavuligerus, an industrially important producer of clavulanate as well as cephem antibiotics, also produces the N-acylated dithiolopyrrolone antibiotic holomycin, a reported inhibitor of RNA synthesis. The genome sequence of S. clavuligerus ATCC 27064 was examined for a potential biosy...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-11, Vol.107 (46), p.19731-19735
Hauptverfasser:	Li, Bo, Walsh, Christopher T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferase Acyltransferases - genetics Acyltransferases - metabolism Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - chemistry Antibiotics Bacterial Proteins - genetics Bacterial Proteins - metabolism Bioinformatics Biological Sciences Biosynthesis cephems Computational Biology Cysteine - metabolism Decarboxylation Enzyme Assays Enzyme kinetics Gene clusters Gene Deletion Gene expression Genes, Bacterial - genetics Genomes Genomics Gram-positive bacteria Lactams - chemistry Lactams - metabolism Multigene family Multigene Family - genetics Mutation Nucleotide sequence Open reading frames Open Reading Frames - genetics Oxidation oxidoreductase phosphopantothenoylcysteine decarboxylase protein purification Protein synthesis Pyrroles - chemistry Pyrroles - metabolism Scaffolds Spectrometry, Mass, Electrospray Ionization Streptomyces Streptomyces - enzymology Streptomyces - genetics Streptomyces clavuligerus Transcription
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