Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation

Uric acid (UA) is known to activate the NLRP3 (Nacht, leucine-rich repeat and pyrin domain containing protein 3) inflammasome. When activated, the NLRP3 (also known as NALP3) inflammasome leads to the production of IL-18 and IL-1β. In this cohort of subjects with knee osteoarthritis (OA), synovial f...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-02, Vol.108 (5), p.2088-2093
Hauptverfasser:	Denoble, Anna E, Huffman, Kim M, Stabler, Thomas V, Kelly, Susan J, Hershfield, Michael S, McDaniel, Gary E, Coleman, R. Edward, Kraus, Virginia B
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Arthritis Biological Sciences Carrier Proteins - genetics Cartilage Cohort Studies Crystals Cytokines Female Gout Humans Immune system Interleukin-1 - blood Interleukin-18 - biosynthesis Joints Knee Knee - pathology Knee joint Knees Male Middle Aged NLR Family, Pyrin Domain-Containing 3 Protein Osteoarthritis Osteoarthritis - blood Osteoarthritis - genetics Osteoarthritis - immunology Pathology Physiology Risk assessment Risk Factors Severity of Illness Index Synovial fluid Uric acid Uric Acid - blood
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