High levels of the Mps1 checkpoint protein are protective of aneuploidy in breast cancer cells

Most human cancers are aneuploid and have chromosomal instability, which contrasts to the inability of human cells to normally tolerate aneuploidy. Noting that aneuploidy in human breast cancer correlates with increased expression levels of the Mps1 checkpoint gene, we investigated whether these hig...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-03, Vol.108 (13), p.5384-5389
Hauptverfasser:	Daniel, Jewel, Coulter, Jonathan, Woo, Ju-Hyung, Wilsbach, Kathleen, Gabrielson, Edward
Format:	Artikel
Sprache:	eng
Schlagworte:	Aneuploidy Animals Apoptosis Apoptosis - physiology Biological Sciences Breast cancer breast neoplasms Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cell culture Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell growth Cell lines Chromosomes Daughter cells Female Gene expression Genes Genomic instability Humans Mice Mice, Nude Mitosis neoplasm cells Neoplasm Transplantation Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Protein-Tyrosine Kinases Proteins RNA Interference RNA-mediated interference Rodents Tumor Cells, Cultured Tumors Xenografts
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