Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells

A previously unappreciated signal necessary for dendritic cell (DC)-mediated activation of natural killer (NK) cells during viral infection was revealed by a recessive N-ethyl-N-nitrosourea-induced mutation called warmflash (wmfl). Wmfl homozygotes displayed increased susceptibility to mouse cytomeg...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-05, Vol.107 (21), p.9759-9764
Hauptverfasser:	Eidenschenk, Céline, Crozat, Karine, Krebs, Philippe, Arens, Ramon, Popkin, Daniel, Arnold, Carrie N., Blasius, Amanda L., Benedict, Chris A., Moresco, Eva Marie Y., Xia, Yu, Beutler, Bruce
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Biological Sciences Cell Survival Cells Cells, Cultured Cytokines Dendritic cells Dendritic Cells - immunology fms-Like Tyrosine Kinase 3 - genetics fms-Like Tyrosine Kinase 3 - immunology Genes Herpesviridae Infections - immunology Homozygotes Infections Killer Cells, Natural - cytology Killer Cells, Natural - immunology Kinases Ligands Lymphocyte Activation Mice Muromegalovirus - immunology Mutation Natural killer cells Rodents Signal Transduction Spleen Splenocytes Viral infections
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