Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise

The cellular basis of age-related behavioral decline remains obscure but alterations in synapses are likely candidates. Accordingly, the beneficial effects on neural function of caloric restriction and exercise, which are among the most effective anti-aging treatments known, might also be mediated b...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-08, Vol.107 (33), p.14863-14868
Hauptverfasser:	Valdez, Gregorio, Tapia, Juan C., Kang, Hyuno, Clemenson, Gregory D., Gage, F. H., Lichtman, Jeff W., Sanes, Joshua R., Fischbach, Gerald D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging Aging - physiology Animals Axon sprouting Axons Biological Sciences Caloric Restriction Comparative analysis Dietary restrictions Exercise Immunohistochemistry Innervation Intervention Life span Luminescent Proteins - genetics Luminescent Proteins - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Microscopy, Confocal Motor neurons Motor Neurons - metabolism Motor Neurons - physiology Muscle fibers Muscle, Skeletal - abnormalities Muscle, Skeletal - metabolism Muscle, Skeletal - physiopathology Muscles Nerves Neuromuscular Junction - abnormalities Neuromuscular Junction - metabolism Neuromuscular Junction - physiopathology Neuromuscular junctions Neurons Physical Conditioning, Animal - physiology Physical training Receptors, Cholinergic - metabolism Rodents Specialization Synapses Synapses - metabolism Wheel running Young adults
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