minority of foci or pan-nuclear apoptotic staining of γH2AX in the S phase after UV damage contain DNA double-strand breaks

UV irradiation induces histone variant H2AX phosphorylated on serine 139 (γH2AX) foci and high levels of pan-nuclear γH2AX staining without foci, but the significance of this finding is still uncertain. We examined the formation of γH2AX and 53BP1 that coincide at sites of double-strand breaks (DSBs...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-04, Vol.107 (15), p.6870-6875
Hauptverfasser:	de Feraudy, Sebastien, Revet, Ingrid, Bezrookove, Vladimir, Feeney, Luzviminda, Cleaver, James E
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis B lymphocytes Biological Sciences Cell cycle Cell lines Cell nucleus Delta cells DNA DNA damage Interphase Irradiation
Online-Zugang:	Volltext
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