Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells

Escherichia coli is a normal inhabitant of the human gut. However, E. coli strains of phylogenetic group B2 harbor a genomic island called "pks" that codes for the production of a polyketide-peptide genotoxin, Colibactin. Here we report that in vivo infection with E. coli harboring the pks...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-06, Vol.107 (25), p.11537-11542
Hauptverfasser:	Cuevas-Ramos, Gabriel, Petit, Claude R., Marcq, Ingrid, Boury, Michèle, Oswald, Eric, Nougayrède, Jean-Philippe, Isberg, Ralph R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaphase Aneuploidy Animals Bacteria Biological Sciences Cell Adhesion Cell cycle Cell division Cell lines Cells CHO Cells Chromosome Aberrations Chromosomes Colonies Colonization Colorectal cancer Cricetinae Cricetulus Digestive tract DNA Damage DNA Repair E coli Enterocytes Epithelial cells Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Genomic Instability Genomics HCT116 cells Infection Infections Intestines - microbiology Islands Life Sciences Mammalian cells Mice Mice, Inbred BALB C Micronuclei Mutagens - metabolism Mutation Neoplasms - metabolism Peptides Phylogenetics Phylogeny Point mutation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!