Protein transduction from retroviral Gag precursors

Retroviral particles assemble a few thousand units of the Gag polyproteins. Proteolytic cleavage mediated by the retroviral protease forms the bioactive retroviral protein subunits before cell entry. We hypothesized that this process could be exploited for targeted, transient, and dose-controlled tr...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-04, Vol.107 (17), p.7805-7810
Hauptverfasser:	Voelkel, Christine, Galla, Melanie, Maetzig, Tobias, Warlich, Eva, Kuehle, Johannes, Zychlinski, Daniela, Bode, Juergen, Cantz, Tobias, Schambach, Axel, Baum, Christopher, Hughes, Stephen H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Cell culture Cell lines Cells Deoxyribonucleic acid DNA Fluorescence Gene Products, gag - biosynthesis Gene Products, gag - genetics Genes Genetic Engineering - methods Genetic vectors Green Fluorescent Proteins - metabolism Kinetics Leukemia Virus, Murine - genetics Leukemia Virus, Murine - metabolism Mice Nuclear Localization Signals - metabolism Peptide Hydrolases - metabolism Pluripotent stem cells Polyproteins Protein precursors Proteins Signal transduction Stem cells Transduction, Genetic - methods Virion - genetics Virion - metabolism Virus Internalization Viruses
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