LXR modulation blocks prostaglandin E 2 production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model

Osteoarthritis (OA), the most common arthritic condition in humans, is characterized by the progressive degeneration of articular cartilage accompanied by chronic joint pain. Inflammatory mediators, such as cytokines and prostaglandin E 2 (PGE 2 ) that are elevated in OA joints, play important roles...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-02, Vol.107 (8), p.3734-3739
Hauptverfasser:	Li, Ning, Rivéra-Bermúdez, Moisés A., Zhang, Mei, Tejada, Julio, Glasson, Sonya S., Collins-Racie, Lisa A., LaVallie, Edward R., Wang, Yihe, Chang, Ken C. N., Nagpal, Sunil, Morris, Elisabeth A., Flannery, Carl R., Yang, Zhiyong
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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