Stepwise acquisition of pyrimethamine resistance in the malaria parasite

The spread of high-level pyrimethamine resistance in Africa threatens to curtail the therapeutic lifetime of antifolate antimalarials. We studied the possible evolutionary pathways in the evolution of pyrimethamine resistance using an approach in which all possible mutational intermediates were crea...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-07, Vol.106 (29), p.12025-12030
Hauptverfasser:	Lozovsky, Elena R, Chookajorn, Thanat, Brown, Kyle M, Imwong, Mallika, Shaw, Philip J, Kamchonwongpaisan, Sumalee, Neafsey, Daniel E, Weinreich, Daniel M, Hartl, Daniel L
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino acids Animals Biological Assay Biological Sciences Drug resistance Drug Resistance - drug effects Ecological competition Enzymes Escherichia coli Evolution Evolution, Molecular Folic acid antagonists Genetic mutation Inhibitory Concentration 50 Malaria Malaria, Falciparum - parasitology Mutagenesis Mutation Parasites Parasites - drug effects Parasites - enzymology Parasites - genetics Parasites - growth & development Parasitic protozoa Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - enzymology Plasmodium falciparum - genetics Plasmodium falciparum - growth & development Polymorphism, Genetic - drug effects Pyrimethamine - pharmacology Tetrahydrofolate Dehydrogenase - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!