Activation of TRPC1 by STIM1 in ER-PM microdomains involves release of the channel from its scaffold caveolin-1

Store-operated Ca²⁺ entry (SOCE) is activated by redistribution of STIM1 into puncta in discrete ER-plasma membrane junctional regions where it interacts with and activates store-operated channels (SOCs). The factors involved in precise targeting of the channels and their retention at these specific...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-11, Vol.106 (47), p.20087-20092
Hauptverfasser:	Pani, Biswaranjan, Ong, Hwei Ling, Brazer, So-ching W, Liu, Xibao, Rauser, Kristina, Singh, Brij B, Ambudkar, Indu S
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Calcium Calcium - metabolism Caveolin 1 - genetics Caveolin 1 - metabolism Cell growth Cell Line Cell Membrane - chemistry Cell Membrane - metabolism Cell membranes Cell Proliferation Cellular immunity Endoplasmic Reticulum - metabolism Endothelial cells Humans Immunoprecipitation Lipids Membrane Microdomains - metabolism Membrane Proteins - genetics Membrane Proteins - metabolism Membranes Mutation Neoplasm Proteins - genetics Neoplasm Proteins - metabolism NF-kappa B - metabolism Physiological regulation Plasma Plasma interactions Protein folding Proteins Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Scaffolds Stromal Interaction Molecule 1 TRPC Cation Channels - genetics TRPC Cation Channels - metabolism
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