Cluster size regulates protein sorting in the immunological synapse

During antigen recognition by T cells, signaling molecules on the T cell engage ligands on the antigen-presenting cell and organize into spatially distinctive patterns. These are collectively known as the immunological synapse (IS). Causal relationships between large-scale spatial organization and s...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-08, Vol.106 (31), p.12729-12734
Hauptverfasser:	Hartman, Niña C, Nye, Jeffrey A, Groves, Jay T
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins Animals Antibodies Antigen-Presenting Cells - immunology Antigens B lymphocytes Biological Sciences Cell adhesion & migration Crosslinking Cytoskeleton Immunological synapses Immunology Intercellular Adhesion Molecule-1 - metabolism Lymphocyte Function-Associated Antigen-1 - metabolism Membrane proteins Mice Molecules Protein Transport Proteins Receptors Receptors, Antigen, T-Cell - physiology Signal Transduction Synapses T cell antigen receptors T cell receptors T lymphocytes T-Lymphocytes - immunology
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