Binding-site geometry and flexibility in DC-SIGN demonstrated with surface force measurements

The dendritic cell receptor DC-SIGN mediates pathogen recognition by binding to glycans characteristic of pathogen surfaces, including those found on HIV. Clustering of carbohydrate-binding sites in the receptor tetramer is believed to be critical for targeting of pathogen glycans, but the arrangeme...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-07, Vol.106 (28), p.11524-11529
Hauptverfasser:	Menon, Sindhu, Rosenberg, Kenneth, Graham, Sarah A, Ward, Eliot M, Taylor, Maureen E, Drickamer, Kurt, Leckband, Deborah E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Adhesiveness Binding sites Binding Sites - genetics Biological Sciences Carbohydrates Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism Dendritic cells Dendritic Cells - immunology Dendritic Cells - metabolism Lectins, C-Type - genetics Lectins, C-Type - metabolism Ligands Lipid bilayers Lipid Bilayers - metabolism Lipids Membranes Models, Molecular Molecules Oligosaccharides Oligosaccharides - metabolism Pathogens Physical Sciences Polysaccharides Protein Binding Protein Conformation Receptors Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism T cell receptors
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