Glutamatergic regulation of serine racemase via reversal of PIP2 inhibition

D-serine is a physiologic coagonist with glutamate at NMDA-subtype glutamate receptors. As D-serine is localized in glia, synaptically released glutamate presumably stimulates the glia to form and release D-serine, enabling glutamate/D-serine cotransmission. We show that serine racemase (SR), which...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-02, Vol.106 (8), p.2921-2926
Hauptverfasser:	Mustafa, Asif K, Rossum, Damian B. van, Patterson, Randen L, Maag, David, Ehmsen, Jeffrey T, Gazi, Sadia K, Chakraborty, Anutosh, Barrow, Roxanne K, Amzel, L. Mario, Snyder, Solomon H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Anisotropy Binding sites Binding, Competitive Biological Sciences Cell Line Cell membranes Enzymes Fluorescence Fluorescence Polarization Glutamic Acid - metabolism HEK293 cells Humans Immunohistochemistry Lipids Membranes Mutation N methyl D aspartate receptors Neuroglia Neurons Neurotransmission Phosphatidylinositol 4,5-Diphosphate - antagonists & inhibitors Phosphatidylinositol 4,5-Diphosphate - metabolism Phospholipids Protein Binding Protein folding Racemases and Epimerases - metabolism Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate - metabolism Tissues
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