Dicer-regulated microRNAs 222 and 339 promote resistance of cancer cells to cytotoxic T-lymphocytes by down-regulation of ICAM-1

The RNase III endonuclease Dicer plays a key role in generation of microRNAs (miRs). We hypothesized that Dicer regulates cancer cell susceptibility to immune surveillance through miR processing. Indeed, Dicer disruption up-regulated intercellular cell adhesion molecule (ICAM)-1 and enhanced the sus...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-06, Vol.106 (26), p.10746-10751
Hauptverfasser:	Ueda, Ryo, Kohanbash, Gary, Sasaki, Kotaro, Fujita, Mitsugu, Zhu, Xinmei, Kastenhuber, Edward R, McDonald, Heather A, Potter, Douglas M, Hamilton, Ronald L, Lotze, Michael T, Khan, Saleem A, Sobol, Robert W, Okada, Hideho
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Blotting, Western Cancer Cell adhesion & migration Cell Line, Tumor Cell lines Cellular immunity Colorectal Neoplasms - immunology Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Cytotoxicity, Immunologic - immunology DEAD-box RNA Helicases - genetics DEAD-box RNA Helicases - metabolism Down-Regulation Flow Cytometry Gene expression Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - pathology Glioma HCT116 Cells Humans Immunohistochemistry In Situ Hybridization Intercellular Adhesion Molecule-1 - genetics Intercellular Adhesion Molecule-1 - metabolism Luciferases - genetics Luciferases - metabolism Lymphocytes Messenger RNA MicroRNA MicroRNAs - genetics Mutation Reverse Transcriptase Polymerase Chain Reaction Ribonuclease III - genetics Ribonuclease III - metabolism Ribonucleic acid RNA RNA Interference RNA, Messenger - genetics RNA, Messenger - metabolism Studies T lymphocytes T-Lymphocytes, Cytotoxic - cytology T-Lymphocytes, Cytotoxic - immunology Transfection Tumor cell line Tumors
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