Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways

During inflammation, a large amount of arachidonic acid (AA) is released into the cellular milieu and cyclooxygenase enzymes convert this AA to prostaglandins that in turn sensitize pain pathways. However, AA is also converted to natural epoxyeicosatrienoic acids (EETs) by cytochrome P450 enzymes. E...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-12, Vol.105 (48), p.18901-18906
Hauptverfasser:	Inceoglu, Bora, Jinks, Steven L, Ulu, Arzu, Hegedus, Christine M, Georgi, Katrin, Schmelzer, Kara R, Wagner, Karen, Jones, Paul D, Morisseau, Christophe, Hammock, Bruce D
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Analgesics - metabolism Animals Biological Sciences Central nervous system Cyclic AMP - metabolism Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism Cytochromes Eicosanoids - chemistry Eicosanoids - metabolism Enzymes Epoxide Hydrolases - antagonists & inhibitors Epoxide Hydrolases - metabolism Epoxy compounds Gene Expression Regulation Genes Inflammation Mice Pain Pain management Pain Measurement Phosphoproteins - genetics Phosphoproteins - metabolism Prostaglandins Rats Receptors Signal Transduction - physiology Spinal cord Steroidogenesis Steroids
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