Immunosuppressive Therapy Mitigates Immunological Rejection of Human Embryonic Stem Cell Xenografts

Given their self-renewing and pluripotent capabilities, human embryonic stem cells (hESCs) are well poised as a cellular source for tissue regeneration therapy. However, the host immune response against transplanted hESCs is not well characterized. In fact, controversy remains as to whether hESCs ha...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-09, Vol.105 (35), p.12991-12996
Hauptverfasser:	Swijnenburg, Rutger-Jan, Schrepfer, Sonja, Govaert, Johannes A., Cao, Feng, Ransohoff, Katie, Sheikh, Ahmad Y., Haddad, Munif, Connolly, Andrew J., Davis, Mark M., Robbins, Robert C., Wu, Joseph C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Formation - drug effects Biological Sciences CD4 antigen CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology Cell Line Cell Survival - drug effects Cellular immunity Computed tomography Data processing Embryo cells Embryonic stem cells Embryonic Stem Cells - drug effects Embryonic Stem Cells - immunology Genes Genes, Reporter Graft rejection Graft Rejection - immunology Graft Rejection - therapy Graft Survival - drug effects Green Fluorescent Proteins - metabolism Humans Immune privilege Immune response Immune response (humoral) Immunity, Cellular - drug effects Immunocompetence - drug effects Immunocompromised Host Immunodeficiency Immunogenicity Immunosuppressants Immunosuppression Immunosuppressive agents Immunosuppressive Agents - pharmacology Immunotherapy Inflammation Lymphocytes T Mice Reporter gene Reporter genes Rodents sirolimus Stem Cell Transplantation Stem cells T lymphocytes Tacrolimus Therapy Tissues Transduction, Genetic Transplantation Transplantation, Heterologous Transplants & implants Xenografts
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