Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism

Human autoimmune (AI) diseases are difficult to treat, because immunosuppressive drugs are nonspecific, produce high levels of adverse effects, and are not based on mechanistic understanding of disease. Destroying the rare autoreactive T lymphocytes causing AI diseases would improve treatment. In an...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-09, Vol.105 (36), p.13644-13649
Hauptverfasser:	Ban, Liqin, Zhang, Jack, Wang, Limei, Kuhtreiber, Willem, Burger, Douglas, Faustman, Denise L
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonism Agonists Apoptosis Apoptosis - drug effects Autoantigens - immunology Biological Sciences Blood Cells Diabetes Diabetes complications Diabetes Mellitus, Type 1 - immunology Humans Insulin Insulin - metabolism Killing Lymphocyte receptors Receptors, Tumor Necrosis Factor, Type II - antagonists & inhibitors Receptors, Tumor Necrosis Factor, Type II - metabolism T cell receptors T lymphocytes T-Lymphocytes - cytology T-Lymphocytes - drug effects T-Lymphocytes - immunology Tumor Necrosis Factor-alpha - pharmacology Type 1 diabetes mellitus
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