Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo

Emerging evidence suggests that myocyte enhancer factor 2 (MEF2) transcription factors act as effectors of neurogenesis in the brain, with MEF2C the predominant isoform in developing cerebrocortex. Here, we show that conditional knockout of Mef2c in nestin-expressing neural stem/progenitor cells (NS...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-07, Vol.105 (27), p.9397-9402
Hauptverfasser:	Li, Hao, Radford, Jonathan C, Ragusa, Michael J, Shea, Katherine L, McKercher, Scott R, Zaremba, Jeffrey D, Soussou, Walid, Nie, Zhiguo, Kang, Yeon-Joo, Nakanishi, Nobuki, Okamoto, Shu-ichi, Roberts, Amanda J, Schwarz, John J, Lipton, Stuart A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Autism Behavior Biological Sciences Brain Cell Differentiation Cognition Developmental biology Electrophysiology Embryonic Development Intellectual disability MEF2 Transcription Factors Mice Mice, Knockout Mitosis Myogenic Regulatory Factors - metabolism Neocortex Neocortex - embryology Neocortex - pathology Neurons Neurons - cytology Neurons - pathology Null condition Phenotype Phenotypes Rodents Stem cells Stem Cells - cytology Synapses Transcription factors Transcription Factors - metabolism
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