Granzyme B delivery via perforin is restricted by size, but not by heparan sulfate-dependent endocytosis

How granzymes gain entry into the cytosol of target cells during killer cell attack has been the subject of several studies in the past, but the effective delivery mechanism during target cell encounter has not been clarified. Here we show that granzyme B (GzmB) mutants lacking binding to negatively...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2008-09, Vol.105 (37), p.13799-13804
Hauptverfasser: Kurschus, Florian C, Fellows, Edward, Stegmann, Elisabeth, Jenne, Dieter E
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Sprache:eng
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