Retinoic acid-stimulated sequential phosphorylation, PML recruitment, and SUMOylation of nuclear receptor TR2 to suppress Oct4 expression

We previously reported an intricate mechanism underlying the homeostasis of Oct4 expression in normally proliferating stem cell culture of P19, mediated by SUMOylation of orphan nuclear receptor TR2. In the present study, we identify a signaling pathway initiated from the nongenomic activity of all-...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-08, Vol.105 (32), p.11424-11429
Hauptverfasser:	Gupta, Pawan, Ho, Ping-Chih, Huq, MD Mostaqul, Ha, Sung Gil, Park, Sung Wook, Khan, Amjad Ali, Tsai, Nien-Pei, Wei, Li-Na
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins Adaptor Proteins, Signal Transducing - metabolism Animals Antineoplastic Agents - pharmacology Biological Sciences Cell Line Embryonic stem cells Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Gene expression regulation Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Genes Genomics Homeostasis - drug effects Homeostasis - physiology MAP Kinase Kinase Kinases - metabolism MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Mice Mitogen-Activated Protein Kinase 1 - metabolism Nuclear Proteins - metabolism Nuclear Receptor Interacting Protein 1 Nuclear Receptor Subfamily 2, Group C, Member 1 Octamer Transcription Factor-3 - biosynthesis Orphans p300-CBP Transcription Factors - metabolism Phosphorylation Phosphorylation - drug effects Pluripotent stem cells Promyelocytic Leukemia Protein Receptors Receptors, Thyroid Hormone - metabolism Repressor Proteins - metabolism Stem cells SUMO-1 Protein - metabolism Transcription Factors - metabolism Tretinoin - pharmacology Tumor Suppressor Proteins - metabolism
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