B7-H3 and B7x Are Highly Expressed in Human Prostate Cancer and Associated with Disease Spread and Poor Outcome

B7-H3 and B7x are recently discovered members of the B7-CD28 family thought to dampen peripheral immune responses via negative costimulation. We evaluated their potential expression in human prostate cancer using a large cohort of patients with 7 years of follow-up. We identified 823 patients with t...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-12, Vol.104 (49), p.19458-19463
Hauptverfasser:	Zang, Xingxing, Thompson, R. Houston, Al-Ahmadie, Hikmat A., Serio, Angel M., Reuter, Victor E., Eastham, James A., Scardino, Peter T., Sharma, Padmanee, Allison, James P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - analysis Antigens, CD - metabolism B7 Antigens B7-1 Antigen - analysis B7-1 Antigen - metabolism Biochemistry Biological Sciences Cancer Cells Disease Progression Gene expression Humans Immunohistochemistry Lymph nodes Male Medical treatment Molecular biology Molecules Pathology Prognosis Prostate cancer Prostatic Neoplasms - diagnosis Prostatic Neoplasms - pathology Receptors, Immunologic - analysis Receptors, Immunologic - metabolism Seminal vesicles Survival Analysis T lymphocytes Tumors V-Set Domain-Containing T-Cell Activation Inhibitor 1
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