Cdx gene deficiency compromises embryonic hematopoiesis in the mouse

Cdx genes (Cdx1, Cdx2, and Cdx4) encode a family of caudal-related transcription factors that mediate anterior-posterior patterning during embryogenesis through Hox gene regulation. Homologues in the zebrafish have been shown to play key roles in blood formation. To define the role of Cdx genes duri...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-06, Vol.105 (22), p.7756-7761
Hauptverfasser:	Wang, Yuan, Yabuuchi, Akiko, McKinney-Freeman, Shannon, Ducharme, Danica M.K, Ray, Manas K, Chawengsaksophak, Kallayanee, Archer, Trevor K, Daley, George Q
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Blood CDX2 Transcription Factor Danio rerio Embryo, Mammalian - cytology Embryo, Mammalian - metabolism Embryonic stem cells Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Embryos Gene expression Genes Hematopoiesis Hematopoiesis - genetics Hematopoietic stem cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Homeodomain Proteins - genetics Homeodomain Proteins - physiology Mice Mice, Knockout P values Progenitor cells Rodents Stem cells Transcription Factors - genetics Transcription Factors - physiology
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