Evolution of adverse changes in stored RBCs

Recent studies have underscored questions about the balance of risk and benefit of RBC transfusion. A better understanding of the nature and timing of molecular and functional changes in stored RBCs may provide strategies to improve the balance of benefit and risk of RBC transfusion. We analyzed cha...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-10, Vol.104 (43), p.17063-17068
Hauptverfasser:	Bennett-Guerrero, Elliott, Veldman, Tim H, Doctor, Allan, Telen, Marilyn J, Ortel, Thomas L, Reid, T. Scott, Mulherin, Melissa A, Zhu, Hongmei, Buck, Raymond D, Califf, Robert M, McMahon, Timothy J
Format:	Artikel
Sprache:	eng
Schlagworte:	2,3-Diphosphoglycerate - metabolism Biological Sciences Blood Blood Preservation - adverse effects Blood transfusion Blood transfusions Cell Hypoxia Cell Shape Erythrocytes Erythrocytes - cytology Erythrocytes - metabolism Evolutionary biology Health outcomes Hemoglobins Hemoglobins - metabolism Humans Hydrogen-Ion Concentration Hypoxia Lactic Acid - metabolism Lesions Mortality Nitric oxide Nitrites Oxygen - metabolism Phosphatidylserines - metabolism Potassium - metabolism Risk S-Nitrosothiols - metabolism Shear Strength Shear stress Time Factors Vasodilation
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