SIK1 is part of a cell sodium-sensing network that regulates active sodium transport through a calcium-dependent process

In mammalian cells, active sodium transport and its derived functions (e.g., plasma membrane potential) are dictated by the activity of the Na⁺,K⁺-ATPase (NK), whose regulation is essential for maintaining cell volume and composition, as well as other vital cell functions. Here we report the existen...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-10, Vol.104 (43), p.16922-16927
Hauptverfasser:	Sjöström, Mattias, Stenström, Karin, Eneling, Kristina, Zwiller, Jean, Katz, Adrian I, Takemori, Hiroshi, Bertorello, Alejandro M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Animals Antibodies Biochemistry Biological Sciences Biological Transport, Active - drug effects Calcium Calcium - metabolism Calcium Signaling - drug effects Carboxylic Ester Hydrolases - metabolism Catalysis - drug effects Catalytic activity Cell free system Cell Line Cell membranes Cells Enzyme Activation - drug effects Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - enzymology Hep G2 cells Humans Ion Transport - drug effects Kidney - cytology Kidney - drug effects Kidney - enzymology Kinases Molecules Opossums Phosphatases Phosphoprotein Phosphatases - metabolism Phosphorylation Phosphorylation - drug effects Physiological regulation Protein Binding - drug effects Protein Phosphatase 2 - metabolism Protein Subunits - metabolism Protein-Serine-Threonine Kinases - metabolism Sodium Sodium - metabolism Sodium - pharmacology Sodium-Potassium-Exchanging ATPase - metabolism
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