Engineering nanoscale order into a designed protein fiber

We have established a designed system comprising two peptides that coassemble to form long, thickened protein fibers in water. This system can be rationally engineered to alter fiber assembly, stability, and morphology. Here, we show that rational mutations to our original peptide designs lead to st...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-06, Vol.104 (26), p.10853-10858
Hauptverfasser:	Papapostolou, David, Smith, Andrew M, Atkins, Edward D.T, Oliver, Seb J, Ryadnov, Maxim G, Serpell, Louise C, Woolfson, Derek N
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biocompatible Materials - chemical synthesis Biological Sciences Biomimetic Materials - chemical synthesis Biophysics Design Design engineering Diffraction patterns Modeling Mutation Nanostructures Nanotechnology Peptides Peptides - chemistry Protein Conformation Protein Engineering - methods Proteins Proteins - chemical synthesis Simulations Water Wave diffraction Waxes X ray diffraction
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