Epigenome scans and cancer genome sequencing converge on WNK2, a kinase-independent suppressor of cell growth

Human cancer genome and epigenome projects aim to identify new cancer genes and targets for therapy that have been overlooked by conventional approaches. Here we integrated large-scale genomics and epigenomics of 31 human infiltrative gliomas and identified low-frequency deletion and highly recurren...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-06, Vol.104 (26), p.10974-10979
Hauptverfasser:	Hong, Chibo, Moorefield, K. Scott, Jun, Peter, Aldape, Kenneth D, Kharbanda, Samir, Phillips, Heidi S, Costello, Joseph F
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Flanking Region Biological Sciences Cancer Cell growth Cell lines CpG Islands DNA Methylation Drug therapy Epigenesis, Genetic Epigenetics Gene Deletion Gene Silencing Genes, Neoplasm Genetic loci Genome, Human Genomics Genomics - methods Glioma Glioma - genetics Glioma - pathology HEK293 cells Humans Inhibitor drugs Kidney cells Kinases Methylation Mutation Neoplasm Invasiveness - genetics Oncology Phosphorylation Point Mutation Promoter regions Promoter Regions, Genetic Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - physiology Simian virus 40 Tumor Suppressor Proteins - genetics Tumors
Online-Zugang:	Volltext
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