Discovery and in vitro Biosynthesis of Haloduracin, a Two-Component Lantibiotic

Lantibiotics are ribosomally synthesized peptides that undergo posttranslational modifications to their mature, antimicrobial form. They are characterized by the unique amino acids lanthionine and methyllanthionine, introduced by means of dehydration of Ser/Thr residues followed by reaction of the r...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-11, Vol.103 (46), p.17243-17248
Hauptverfasser:	McClerren, Amanda L., Cooper, Lisa E., Quan, Chao, Thomas, Paul M., Kelleher, Neil L., van der Donk, Wilfred A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetoacetates - metabolism Adducts Amino Acid Sequence Amino acids Antibiotics Antimicrobials Bacillus - chemistry Bacillus - genetics Bacillus - metabolism Bacillus halodurans Bacteria Bacterial Proteins - biosynthesis Bacterial Proteins - chemistry Bacteriocins Bacteriocins - biosynthesis Bacteriocins - chemistry Biological Sciences Biosynthesis Chemical synthesis Cytotoxins Dehydration Enzymes Factor Xa - metabolism Genomes Genomics Iodoacetamide - chemistry Iodoacetamide - metabolism Molecular Sequence Data Peptides Protein Engineering Proteins Sequence Alignment Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Online-Zugang:	Volltext
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